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Proceedings Paper

In-vivo human retinal imaging with pulsed illumination spectral-domain optical coherence tomography
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Paper Abstract

We present pulsed illumination spectral-domain optical coherence tomography (SD-OCT) for in vivo human retinal imaging. We analyze the signal-to-noise (SNR) for continuous wave (CW) and pulsed illumination SD-OCT. The lateral beam scan motion is responsible for a SNR drop due to lateral scanning induced interference fringe washout. Pulsed illumination can reduce the SNR drop by shorter sample illumination time during the integration time of a camera. First, we demonstrate the SNR benefit of pulsed illumination over CW as function of lateral scan speed for a paper sample. For in-vivo human retinal imaging with pulsed illumination, the maximum permissible exposure (MPE) according to pulse repetition rate is presented based on ANSI standard. Finally, we show better SNR in retinal images of a normal subject with pulsed illumination SD-OCT over CW at high lateral scanning speed.

Paper Details

Date Published: 7 February 2007
PDF: 9 pages
Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 642912 (7 February 2007); doi: 10.1117/12.701240
Show Author Affiliations
Jang-Woo You, Korea Advanced Institute of Science and Technology (South Korea)
Teresa C. Chen, Massachusetts Eye and Ear Infirmary, Harvard Medical School (United States)
Mircea Mujat, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
B. Hyle Park, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Johannes F. de Boer, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 6429:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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