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Proceedings Paper

Enhancing PDT drug delivery by enzymatic cleavage of porphyrin phosphates
Author(s): Bing Xu; Gaolin Liang; Ling Wang; Zhimou Yang; Kalok Chan; Chi K. Chang
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Paper Abstract

A new anionic porphyrin-phosphate conjugate has been made as the substrate of phosphatase to evaluate its cellular-uptake and potential targeting on cancer cells, taking advantage of the over-expression of phosphatases associated with the development of cancers. The phosphate groups increase the hydrophilicity of porphyrin dityrosine phosphate and facilitate its formulation in aqueous solvent. Upon hydrolysis by phosphatase after cellular uptaking, the more hydrophobic porphyrin-dityrosine promises to give better cellular retention. Indeed, the phosphate conjugate displayed a much better PDT effect than that of the parent porphyrin at the same concentration (10 &mgr;M) and light dosage on HeLa cells, indicating the enzyme-cleavage reaction occurred in HeLa cells plays a role. Photosenzitizers utilizing enzyme-cleavage might be a promising approach for photodynamic therapy.

Paper Details

Date Published: 28 February 2007
PDF: 6 pages
Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64271A (28 February 2007); doi: 10.1117/12.701185
Show Author Affiliations
Bing Xu, Hong Kong Univ. of Science and Technology (Hong Kong China)
Gaolin Liang, Hong Kong Univ. of Science and Technology (Hong Kong China)
Ling Wang, Hong Kong Univ. of Science and Technology (Hong Kong China)
Zhimou Yang, Hong Kong Univ. of Science and Technology (Hong Kong China)
Kalok Chan, Hong Kong Univ. of Science and Technology (Hong Kong China)
Chi K. Chang, Hong Kong Univ. of Science and Technology (Hong Kong China)


Published in SPIE Proceedings Vol. 6427:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
David Kessel, Editor(s)

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