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Proceedings Paper

Phantom study on combined cw and time-domain fluorescence mammography
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Paper Abstract

We have carried out phantom studies for optimizing the design of a fluorescence mammograph employing time-domain and cw measurements, for improving data analysis and methods of reconstruction. By scanning pulsed (100 fs) laser radiation across a fluorescent, rectangular breast-like phantom with a spherical inhomogeneity simulating a tumor bearing breast slightly compressed between two parallel glass plates, distributions of times of flight of laser and fluorescence photons were measured in transmission and reflection for various detector arrangements. Absorption coefficients and dye concentrations were reconstructed using perturbation solutions of the diffusion equation at the laser and fluorescence wavelengths. We additionally employed a CCD camera to measure time-integrated intensity of fluorescence and laser radiation transmitted through the phantom. The increased number of projection angles entering the reconstruction improved spatial resolution. Further improvements were obtained when combined cw data and time-resolved remission data were used in the reconstruction.

Paper Details

Date Published: 13 February 2007
PDF: 15 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64340I (13 February 2007); doi: 10.1117/12.700973
Show Author Affiliations
D. Grosenick, Physikalisch-Technische Bundesanstalt (Germany)
O. Steinkellner, Physikalisch-Technische Bundesanstalt (Germany)
A. Hagen, Physikalisch-Technische Bundesanstalt (Germany)
R. Ziegler, Philips Research Europe (Germany)
T. Nielsen, Philips Research Europe (Germany)
R. Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
H. Rinneberg, Physikalisch-Technische Bundesanstalt (Germany)


Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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