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Proceedings Paper

Characterization of laser-induced thermal response of nanoshells for cancer treatment using magnetic-resonance temperature imaging
Author(s): Andrew M. Elliott; R. Jason Stafford; Jon Schwartz; James Wang; Anil M. Shetty; Chris Bourgoyne; D. Patrick O'Neal; John D. Hazle
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Paper Abstract

Laser induced thermal therapy is used in conjunction with gold coated silica core nanoshells and magneticresonance temperature imaging (MRTI). The nanoshells are embedded in phantom or in vivo tumors and heat preferentially compared to surrounding tissue when the laser is applied. The tissues thermal response is varied by either the laser power or the nanoshell concentration. In this way precise control of the heating can be achieved. This results in the ability to quantitatively monitor therapeutic temperature changes that occur in a spatiotemporally controlled way. This provides an unprecedented means proscribing and monitoring a treatment in real time and the ability to make precise corrections when necessary.

Paper Details

Date Published: 9 February 2007
PDF: 9 pages
Proc. SPIE 6440, Thermal Treatment of Tissue: Energy Delivery and Assessment IV, 64400G (9 February 2007); doi: 10.1117/12.700957
Show Author Affiliations
Andrew M. Elliott, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
R. Jason Stafford, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jon Schwartz, Nanospectra Biosciences, Inc. (United States)
James Wang, Nanospectra Biosciences, Inc. (United States)
Anil M. Shetty, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Chris Bourgoyne, Nanospectra Biosciences Inc. (United States)
D. Patrick O'Neal, Louisiana Tech Univ. (United States)
John D. Hazle, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 6440:
Thermal Treatment of Tissue: Energy Delivery and Assessment IV
Thomas P. Ryan, Editor(s)

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