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Proceedings Paper

Needle-probe system for the measurement of tissue refractive index
Author(s): Adam M. Zysk; Steven G. Adie; Julian J. Armstrong; Matthew S. Leigh; Alexandre Paduch; Freddy T. Nguyen; David D. Sampson; Stephen A. Boppart M.D.
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Paper Abstract

Needle-based devices, which are in wide clinical use for needle biopsy procedures, may be augmented by suitable optical techniques for the localization and diagnosis of diseased tissue. Tissue refractive index is one optical contrast mechanism with diagnostic potential. In the case of mammary tissue, for example, recent research indicates that refractive index variations between tissue types may be useful for the identification of cancerous tissue. While many coherence-based forward-sensing devices have been developed to detect scattering changes, none have demonstrated refractive index measurement capabilities. We present a novel needle-based device that is capable of simultaneously measuring refractive index and scattering. Coupled to the sample arm of an optical coherence tomography system, the needle device detects the scattering response and optical pathlength through tissue residing in a fixed-width channel. Near-infrared measurements of tissues and materials with known optical properties using a prototype device will be presented. This work demonstrates the feasibility of integrated in vivo measurement of refractive index and scattering in conjunction with existing clinical needle-based devices.

Paper Details

Date Published: 6 February 2007
PDF: 8 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64300O (6 February 2007); doi: 10.1117/12.700955
Show Author Affiliations
Adam M. Zysk, Univ. of Illinois at Urbana-Champaign (United States)
Steven G. Adie, Univ. of Western Australia (Australia)
Julian J. Armstrong, Univ. of Western Australia (Australia)
Matthew S. Leigh, Univ. of Western Australia (Australia)
Alexandre Paduch, Univ. of Western Australia (Australia)
Freddy T. Nguyen, Univ. of Illinois at Urbana-Champaign (United States)
David D. Sampson, Univ. of Western Australia (Australia)
Stephen A. Boppart M.D., Univ. of Illinois at Urbana-Champaign (United States)


Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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