Share Email Print
cover

Proceedings Paper

Imaging of eye tumor in the mouse model of retinoblastoma with spectral-domain optical coherence tomography
Author(s): Shuliang Jiao; Marco Ruggeri; Hassan Wehbe; Giovanni Gregory; Maria E. Jockovich; Abigail Hackam; Carmen A. Puliafito
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Noninvasive in vivo examination of the rodent retina without sacrificing the animal is the key to being able to perform longitudinal studies. This allows the monitoring of disease progression and the response to therapies through its entire course in individual animal. A high-speed high resolution three-dimensional spectral-domain OCT is built for non-contact in vivo imaging of rodent retina. The system is able to acquire high quality 3D images of the rodent retina in 2.7 seconds (total imaging time is ~5 minutes). The system was tested on mice with normal retina (B6/SJLF2), mouse model for photoreceptor degeneration (Rho-/-), and mouse model for retinoblastoma (LHBETATAG). For the first time to our knowledge, 3D image of the tumor in retinoblastoma mouse model was successfully imaged in vivo. By segmenting the tumor boundaries in each frame of the OCT image the volume of the tumor was successfully calculated.

Paper Details

Date Published: 5 March 2007
PDF: 4 pages
Proc. SPIE 6426, Ophthalmic Technologies XVII, 64260D (5 March 2007); doi: 10.1117/12.700338
Show Author Affiliations
Shuliang Jiao, Univ. of Miami Miller School of Medicine (United States)
Marco Ruggeri, Univ. of Miami Miller School of Medicine (United States)
Hassan Wehbe, Univ. of Miami Miller School of Medicine (United States)
Giovanni Gregory, Univ. of Miami Miller School of Medicine (United States)
Maria E. Jockovich, Univ. of Miami Miller School of Medicine (United States)
Abigail Hackam, Univ. of Miami Miller School of Medicine (United States)
Carmen A. Puliafito, Univ. of Miami Miller School of Medicine (United States)


Published in SPIE Proceedings Vol. 6426:
Ophthalmic Technologies XVII
Bruce E. Stuck; Fabrice Manns; Per G. Söderberg; Michael Belkin; Arthur Ho, Editor(s)

© SPIE. Terms of Use
Back to Top