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Proceedings Paper

Photoacoustic imaging of tumor vascularization on nude mice
Author(s): Bson Chiu; Shu-Wei Huang; Huihua Kenny Chiang
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Paper Abstract

Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast than conventional ultrasound imaging due to the high contrast absorption of blood on green and near infrared (NIR) light. We conducted in-vivo PAI of tumor blood vessels - monitoring 3-24 days development of tumor after the implant of the tumor cells on the back of nude mice. We observed that the PAI signals increased with the blood vessel developments and the growth of the tumor. This study shows that PAI is suitable for monitoring of the development of blood vessels near the superficial tumors. These results demonstrate the usefulness of the PAI for tumor angiogenesis monitoring in small animals.

Paper Details

Date Published: 13 February 2007
PDF: 7 pages
Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370T (13 February 2007); doi: 10.1117/12.700255
Show Author Affiliations
Bson Chiu, National Yang-Ming Univ. (Taiwan)
Shu-Wei Huang, National Yang-Ming Univ. (Taiwan)
Huihua Kenny Chiang, National Yang-Ming Univ. (Taiwan)
Taipei City Hospital (Taiwan)


Published in SPIE Proceedings Vol. 6437:
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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