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Proceedings Paper

Optical coherence tomography in the diagnosis of dysplasia and adenocarcinoma in Barret's esophagus
Author(s): N. D. Gladkova; E. V. Zagaynova; G. Zuccaro; Margarita V. Kareta; F. I. Feldchtein; Irina V. Balalaeva; Elena B. Balandina
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Paper Abstract

Statistical analysis of endoscopic optical coherence tomography (EOCT) surveillance of 78 patients with Barrett's esophagus (BE) is presented in this study. The sensitivity of OCT device in retrospective open detection of early malignancy (including high grade dysplasia and intramucosal adenocarcinoma (IMAC)) was 75%, specificity 82%, diagnostic accuracy - 80%, positive predictive value- 60%, negative predictive value- 87%. In the open recognition of IMAC sensitivity was 81% and specificity were 85% each. Results of a blind recognition with the same material were similar: sensitivity - 77%, specificity 85%, diagnostic accuracy - 82%, positive predictive value- 70%, negative predictive value- 87%. As the endoscopic detection of early malignancy is problematic, OCT holds great promise in enhancing the diagnostic capability of clinical GI endoscopy.

Paper Details

Date Published: 12 February 2007
PDF: 9 pages
Proc. SPIE 6432, Endoscopic Microscopy II, 64320A (12 February 2007); doi: 10.1117/12.700254
Show Author Affiliations
N. D. Gladkova, Institute of Applied Physics (Russia)
E. V. Zagaynova, Nizhny Novgorod State Medical Academy (Russia)
G. Zuccaro, Cleveland Clinic Foundation (United States)
Margarita V. Kareta, Imalux Corp. (United States)
F. I. Feldchtein, Imalux Corp. (United States)
Irina V. Balalaeva, Institute of Applied Physics (Russia)
Elena B. Balandina, Nizhny Novgorod State Medical Academy (Russia)

Published in SPIE Proceedings Vol. 6432:
Endoscopic Microscopy II
Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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