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Proceedings Paper

Study on diagnosis of micro-biomechanical structure using optical coherence tomography
Author(s): Souichi Saeki; Youhei Hashimoto; Takashi Saito; Takafumi Hiro; Masunori Matsuzaki
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Paper Abstract

Acute coronary syndromes, e.g. myocardial infarctions, are caused by the rupture of unstable plaques on coronary arteries. The stability of plaque, which depends on biomechanical properties of fibrous cap, should be diagnosed crucially. Recently, Optical Coherence Tomography (OCT) has been developed as a cross-sectional imaging method of microstructural biological tissue with high resolution 1~10 &mgr;m. Multi-functional OCT system has been promising, e.g. an estimator of biomechanical characteristics. It has been, however, difficult to estimate biomechanical characteristics, because OCT images have just speckle patterns by back-scattering light from tissue. In this study, presented is Optical Coherence Straingraphy (OCS) on the basis of OCT system, which can diagnose tissue strain distribution. This is basically composed of Recursive Cross-correlation technique (RC), which can provide a displacement vector distribution with high resolution. Furthermore, Adjacent Cross-correlation Multiplication (ACM) is introduced as a speckle noise reduction method. Multiplying adjacent correlation maps can eliminate anomalies from speckle noise, and then can enhance S/N in the determination of maximum correlation coefficient. Error propagation also can be further prevented by introducing to the recursive algorithm (RC). In addition, the spatial vector interpolation by local least square method is introduced to remove erroneous vectors and smooth the vector distribution. This was numerically applied to compressed elastic heterogeneous tissue samples to carry out the accuracy verifications. Consequently, it was quantitatively confirmed that its accuracy of displacement vectors and strain matrix components could be enhanced, comparing with the conventional method. Therefore, the proposed method was validated by the identification of different elastic objects with having nearly high resolution for that defined by optical system.

Paper Details

Date Published: 7 February 2007
PDF: 9 pages
Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 64292R (7 February 2007); doi: 10.1117/12.700132
Show Author Affiliations
Souichi Saeki, Yamaguchi Univ. (Japan)
Youhei Hashimoto, Yamaguchi Univ. (Japan)
Takashi Saito, Yamaguchi Univ. (Japan)
Takafumi Hiro, Yamaguchi Univ. (Japan)
Masunori Matsuzaki, Yamaguchi Univ. (Japan)


Published in SPIE Proceedings Vol. 6429:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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