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Proceedings Paper

Interstitial photodynamic therapy for primary prostate cancer incorporating real-time treatment dosimetry
Author(s): Ann Johansson; Johan Axelsson; Johannes Swartling; Thomas Johansson; Sara Pålsson; Johan Stensson; Margret Einarsdóttír; Katarina Svanberg M.D.; Niels Bendsoe; Karl Mikael Kälkner; Sten Nilsson; Sune Svanberg; Stefan Andersson-Engels
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Paper Abstract

Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and short-term response to the therapeutic irradiation. Within our group, an instrument for interstitial PDT on prostate tissue that incorporates realtime treatment feedback is being developed. The treatment protocol consists of two parts. The first part incorporates the pre-treatment plan with ultrasound investigations, providing the geometry for the prostate gland and surrounding risk organs, an iterative random-search algorithm to determine near-optimal fiber positions within the reconstructed geometry and a Block-Cimmino optimization algorithm for predicting individual fiber irradiation times. During the second part, the therapeutic light delivery is combined with measurements of the light transmission signals between the optical fibers, thus monitoring the tissue effective attenuation coefficient by means of spatially resolved spectroscopy. These data are then used as input for repeated runs of the Block-Cimmino optimization algorithm. Thus, the irradiation times for individual fibers are updated throughout the treatment in order to compensate for the influence of changes in tissue composition on the light distribution at the therapeutic wavelength.

Paper Details

Date Published: 27 February 2007
PDF: 11 pages
Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64270O (27 February 2007); doi: 10.1117/12.699903
Show Author Affiliations
Ann Johansson, Lund Univ. (Sweden)
Johan Axelsson, Lund Univ. (Sweden)
Johannes Swartling, SpectraCure AB (Sweden)
Thomas Johansson, SpectraCure AB (Sweden)
Sara Pålsson, SpectraCure AB (Sweden)
Johan Stensson, SpectraCure AB (Sweden)
Margret Einarsdóttír, Lund Univ. Hospital (Sweden)
Katarina Svanberg M.D., Lund Univ. Hospital (Sweden)
Niels Bendsoe, Lund Univ. Hospital (Sweden)
Karl Mikael Kälkner, Karolinska Univ. Hospital (Sweden)
Sten Nilsson, Karolinska Univ. Hospital (Sweden)
Sune Svanberg, Lund Univ. (Sweden)
Stefan Andersson-Engels, Lund Univ. (Sweden)

Published in SPIE Proceedings Vol. 6427:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
David Kessel, Editor(s)

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