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Proceedings Paper

A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis
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Paper Abstract

A theoretical framework is presented that allows a lifetime based analysis of the entire temporal diffuse fluorescence response curve from a turbid medium. Optimization studies using singular value decomposition analysis show that direct time domain fluorescence reconstructions are optimally performed using a few points near the peak and rise portions of the temporal response. It is also shown that the initial portion of the fluorescent response curve offers superior contrast-to-noise performance, while the late decay portions offer minimal cross-talk between multiple lifetime components.

Paper Details

Date Published: 1 March 2007
PDF: 9 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64340E (1 March 2007); doi: 10.1117/12.699692
Show Author Affiliations
Anand T. N. Kumar, Massachusetts General Hospital, Harvard Medical School (United States)
Scott B. Raymond, Harvard-MIT Division of Health Sciences and Technology (United States)
David A. Boas, Massachusetts General Hospital, Harvard Medical School (United States)
Brian J. Bacskai, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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