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Proceedings Paper

Analysis of colon tumors in rats by near-infrared Raman spectroscopy
Author(s): Janaína Duarte; Raduan Hage; Landulfo Silveira; Fabricio Silveira; Marcos Tadeu T. Pacheco; Egberto Munin; Hélio Plapler
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Paper Abstract

Biomedical applications of near-infrared Raman spectroscopy have increased their importance at the last ten years. This technique can determinate the molecular composition of materials, allowing a sensible and fast biological diagnosis. It has showed to be a promising tool for health diagnosis due to its high sensibility. Colorectal cancer (CRC) is one of the most common malignant tumors in humans beings. In the last decades many experimental models have been developed in animals based in the use of chemical composites to induce the formation and development of these tumors, many of them present similar characteristics to those of natural occurrence aiming to the attainment of information on genesis, evolution, as well as diagnosis and more efficient therapies for treating these neoplasias. Amongst the most used chemical composites is the 1,2- dimetilhydrazine (DMH) because its morphological and histological similarity to those tumors. This study aims to compare in vivo normal colon tissue and tumoral colon tissue, induced by DMH, in rats by near-infrared Raman spectroscopy to permit the use in the near future for an efficient diagnosis in real time besides being useful as an auxiliary method for several therapies, including the photodynamic therapy.

Paper Details

Date Published: 28 February 2007
PDF: 6 pages
Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 642714 (28 February 2007); doi: 10.1117/12.699690
Show Author Affiliations
Janaína Duarte, Univ. Federal de São Paulo (Brazil)
Univ. do Vale do Paraíba (Brazil)
Raduan Hage, Univ. Federal de São Paulo (Brazil)
Landulfo Silveira, Univ. do Vale do Paraíba (Brazil)
Fabricio Silveira, Univ. do Vale do Paraíba (Brazil)
Marcos Tadeu T. Pacheco, Univ. do Vale do Paraíba (Brazil)
Egberto Munin, Univ. do Vale do Paraíba (Brazil)
Hélio Plapler, Univ. Federal de São Paulo (Brazil)


Published in SPIE Proceedings Vol. 6427:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
David Kessel, Editor(s)

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