Share Email Print
cover

Proceedings Paper

Pulse laser integrated photodynamic therapy and photoacoustic imaging
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

A unique photoacoustic system was developed for neovascular imaging during tumor photodynamic therapy (PDT). In this system, a single pulse laser beam is used as the light source for both PDT treatment and for concurrently generating ultrasound signals for photoacoustic imaging. To demonstrate its feasibility, this system was used to observe vascular changes during PDT treatment of chicken chorioallantoic membrane (CAM) tumors. The photosensitizer used in this study was protoporphyrin IX (PpIX) and the laser wavelength was 532 nm. Damage of the vascular structures by PDT was imaged before, during and after treatment. Rapid, real-time determination of the size of targeted tumor blood vessels was achieved, using time difference of positive and negative ultrasound peaks during PDT treatment. The experimental results show that a pulse laser can be conveniently used to hybridize PDT treatment and photoacoustic imaging and that this integrated system is capable of quantitatively monitoring the structural change of blood vessels during PDT. This method could be potentially used to guide PDT and other phototherapies using vascular changes during treatment to optimize treatment protocols, by choosing appropriate types and doses of photosensitizers, and doses of light.

Paper Details

Date Published: 13 February 2007
PDF: 8 pages
Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64372B (13 February 2007); doi: 10.1117/12.698771
Show Author Affiliations
Liangzhong Xiang, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)
Huaimin Gu, South China Normal Univ. (China)
Diwu Yang, South China Normal Univ. (China)
Sihua Yang, South China Normal Univ. (China)
Lvming Zeng, South China Normal Univ. (China)
Wei R. Chen, South China Normal Univ. (China)


Published in SPIE Proceedings Vol. 6437:
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top