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Proceedings Paper

Photoacoustic detection of circulating melanoma cells in vitro
Author(s): Ryan M. Weight; Paul S. Dale; Gerardo Gutierrez-Juarez; Charles W. Caldwell; Allison B. Lisle; John A. Viator
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Paper Abstract

The prognostic value of exposing malignant melanoma poses an urgent need for an efficient, accurate screening method for metastatic cells. We propose a system for the detection of metastatic tumor cells based upon the thermo-elastic properties of melanoma. The method employs photoacoustic excitation coupled with a detection system capable of exposing cells within the circulatory system in vitro. Initial trials provided a threshold on the order of ten individual cells. Results imply the potential to assay simple blood draws for the presence of cancerous melanoma providing an unprecedented method for routine cancer screening.

Paper Details

Date Published: 13 February 2007
PDF: 5 pages
Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643708 (13 February 2007); doi: 10.1117/12.698712
Show Author Affiliations
Ryan M. Weight, Kansas City Univ. of Medicine and Biosciences (United States)
Paul S. Dale, Univ. of Missouri/Columbia (United States)
Gerardo Gutierrez-Juarez, Univ. of Guanajuato (Mexico)
Charles W. Caldwell, Univ. of Missouri/Columbia (United States)
Allison B. Lisle, Univ. of Missouri/Columbia (United States)
John A. Viator, Univ. of Missouri/Columbia (United States)


Published in SPIE Proceedings Vol. 6437:
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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