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Proceedings Paper

Iron-oxide nanoparticles as a contrast agent in thermoacoustic tomography
Author(s): Xing Jin; Aaron Keho; Kenith Meissner; Lihong V. Wang
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Paper Abstract

We investigate the feasibility of using iron oxide nanoparticles as a contrast agent for radiofrequency (RF) induced thermoacoustic tomography. Aqueous colloids of iron oxide (Fe3O4) nanoparticles have been synthesized and characterized. The synthesis method yielded citrate-stabilized, spherical particles with a diameter of approximately 10 nm. The complex permittivity of the colloids was measured with a coaxial probe and vector network analyzer, and the microwave absorption properties were calculated by using a relationship between the complex permittivity and absorption coefficients. Using our pulsed thermoacoustic imaging system at 3 GHz, the time-resolved thermoacoustic responses of those colloids were measured and compared to that of deionized water. Finally, two-dimensional thermoacoustic images were acquired from iron oxide colloids in a tissue phantom. The iron oxide colloids produced an enhancement in RF absorption of up to three times that of deionized water at 3 GHz. The enhancement increased rapidly with decreasing frequency of the RF excitation source. A corresponding increase in time-resolved thermoacoustic signal of more than two times was demonstrated. Our results indicate that iron oxide nanoparticles have the potential to produce enhanced thermoacoustic signals and to provide molecular imaging with functionalized contrast agents for thermoacoustic tomography.

Paper Details

Date Published: 13 February 2007
PDF: 7 pages
Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370E (13 February 2007); doi: 10.1117/12.698329
Show Author Affiliations
Xing Jin, Texas A&M Univ. (United States)
Aaron Keho, Texas A&M Univ. (United States)
Kenith Meissner, Texas A&M Univ. (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 6437:
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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