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Proceedings Paper

Optical coherence tomography of the rat cavernous nerves
Author(s): Nathaniel M. Fried; Soroush Rais-Bahrami; Gwen A. Lagoda; Ying Chuang; Arthur L. Burnett; Li-Ming Su
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Paper Abstract

Improvements in identification, imaging, and visualization of the cavernous nerves during radical prostatectomy, which are responsible for erectile function, may improve nerve preservation and postoperative potency. Optical coherence tomography (OCT) is capable of real-time, high-resolution, cross-sectional, in vivo tissue imaging. The rat prostate serves as an excellent model for studying the use of OCT for imaging the cavernous nerves, as the rat cavernous nerve is a large, visible, and distinct bundle allowing for easy identification with OCT in addition to histologic confirmation. Imaging was performed with the Niris OCT system and a handheld 8 Fr probe, capable of acquiring real-time images with 11-&mgr;m axial and 25-&mgr;m lateral resolution in tissue. Open surgical exposure of the prostate was performed on a total of 6 male rats, and OCT images of the prostate, cavernous nerve, pelvic plexus ganglion, seminal vesicle, blood vessels, and periprostatic fat were acquired. Cavernous nerve electrical stimulation with simultaneous intracorporeal pressure measurements was performed to confirm proper identification of the cavernous nerves. The prostate and cavernous nerves were also processed for histologic analysis and further confirmation. Cross-sectional and longitudinal OCT images of the cavernous nerves were acquired and compared with histologic sections. The cavernous nerve and ganglion could be differentiated from the surrounding prostate gland, seminal vesicle, blood vessels, bladder, and fatty tissue. We report preliminary results of OCT images of the rat cavernous nerves with histologic correlation and erectile stimulation measurements, thus providing interpretation of prostate structures as they appear in OCT images.

Paper Details

Date Published: 23 March 2007
PDF: 8 pages
Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 64240W (23 March 2007); doi: 10.1117/12.697940
Show Author Affiliations
Nathaniel M. Fried, Johns Hopkins Medical Institutions (United States)
Univ. of North Carolina at Charlotte (United States)
Soroush Rais-Bahrami, Johns Hopkins Medical Institutions (United States)
Gwen A. Lagoda, Johns Hopkins Medical Institutions (United States)
Ying Chuang, Johns Hopkins Medical Institutions (United States)
Arthur L. Burnett, Johns Hopkins Medical Institutions (United States)
Li-Ming Su, Johns Hopkins Medical Institutions (United States)


Published in SPIE Proceedings Vol. 6424:
Photonic Therapeutics and Diagnostics III
Henry Hirschberg; Steen J. Madsen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Reza S. Malek; Kenton W. Gregory; Guillermo J. Tearney; Nikiforos Kollias; Bernard Choi; Haishan Zeng, Editor(s)

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