Share Email Print
cover

Proceedings Paper

Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection
Author(s): Xingwei Wang; Juncheng Xu; Zhuang Wang; Kristie L. Cooper; Anbo Wang; Chengdong Cao
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

This paper presents a novel fiber optic Fabry-Perot (FP) structure for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic self-assembly (L-b-L ESA) technique. With the FP cavity inside the fiber, the change in optical path length difference (OPD) caused by the immobilization and hybridization can be demodulated. Experimental results demonstrate short (~5 min) response time. In addition, the sensor fabrication is simple and low cost. The signal is stable with high visibility.

Paper Details

Date Published: 13 February 2007
PDF: 8 pages
Proc. SPIE 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV, 64490G (13 February 2007); doi: 10.1117/12.697431
Show Author Affiliations
Xingwei Wang, Virginia Polytechnic Institute and State Univ. (United States)
Univ. of Massachusetts Lowell (United States)
Juncheng Xu, Virginia Polytechnic Institute and State Univ. (United States)
Zhuang Wang, Virginia Polytechnic Institute and State Univ. (United States)
Kristie L. Cooper, Virginia Polytechnic Institute and State Univ. (United States)
Anbo Wang, Virginia Polytechnic Institute and State Univ. (United States)
Chengdong Cao, Water Saving Office (China)


Published in SPIE Proceedings Vol. 6449:
Genetically Engineered and Optical Probes for Biomedical Applications IV
Samuel Achilefu; Darryl J. Bornhop; Ramesh Raghavachari; Alexander Pavlovich Savitsky; Rebekka M. Wachter, Editor(s)

© SPIE. Terms of Use
Back to Top