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Proceedings Paper

Group analysis of FMRI and NIR data simultaneously acquired during visual stimulation in humans
Author(s): Vladislav Y. Toronov; Xiaofeng Zhang; Andrew G. Webb
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Paper Abstract

We use our new combined functional near infrared spectro-imaging (fNIRSI) and magnetic resonance imaging (MRI) technique to compare fMRI and fNIRSI data at different activation conditions, to obtain new information about the underlying physiology of the blood oxygen level dependent (BOLD) signal used in fMRI, and to assess statistical characteristics of spatial functional information provided by the group analysis of fNIRSI data. To achieve these goals we have acquired simultaneously fNIRSI and fMRJ data during the presentation of the checkerboard reversing with different frequencies, and analyzed these data following the standard correlation and group analysis of variance pathway used in functional neuroimaging. We have found that while the time courses of oxy-, deoxy-, and total- hemoglobin responses are equally well correlated with the time course of the BOLD response, the spatial pattern and magnitude of the BOLD response is better related to those of the oxy-, and total- hemoglobin responses rather than to the deoxyhemoglobin response. The statistical significance of the fNIRSI group maps is inferior to that of fMRI, and can be particularly compromised by the anatomical features of subjects.

Paper Details

Date Published: 21 July 2006
PDF: 9 pages
Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 61630S (21 July 2006); doi: 10.1117/12.697069
Show Author Affiliations
Vladislav Y. Toronov, Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)
Xiaofeng Zhang, Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)
Andrew G. Webb, Beckman Institute for Advanced Science and Technology, Univ. of Illinois at Urbana-Champaign (United States)


Published in SPIE Proceedings Vol. 6163:
Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Valery V. Tuchin, Editor(s)

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