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Proceedings Paper

Comparative study of optical coherence tomography, photoacoustic technique, and time-of-flight technique in phantom measurements
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Paper Abstract

of biomedical imaging techniques, the optical coherence tomography (OCT), photoacoustic (PA) and time-of-flight (TOF) techniques are among the most researched and, consequently, increasingly broadly applied. This article reviews their basic principles, compares their technical aspects and discusses their ability to determine optical parameters. Also studied is their applicability to non-invasive glucose monitoring in IntralipidTM phantom measurements, followed by a discussion of some detected problems. Although suffering from a limited probing depth, OCT was found to have the best capacity for detecting changes in the light scattering properties of IntralipidTM. Photon migration studies with the TOF technique showed changes in pulse amplitude, pulse width and arrival time of the pulse maximum as a function of changes in IntralipidTM concentration, whereas the sensitivity of the PA technique for detecting changes in scattering was less pronounced. However, each technique showed changes in the registered signals when measuring large glucose concentrations in IntralipidTM phantoms. Measurement results were also affected by the varying measurement geometries and the photon energies of the light sources.

Paper Details

Date Published: 21 July 2006
PDF: 13 pages
Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616304 (21 July 2006); doi: 10.1117/12.696930
Show Author Affiliations
Matti Kinnunen, Optoelectronics Measurement Techniques Lab. and Infotech Oulu, Univ. of Oulu (Finland)
Risto Myllylä, Optoelectronics Measurement Techniques Lab. and Infotech Oulu, Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 6163:
Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII

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