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Proceedings Paper

Monitoring of drug diffusion in ocular tissues
Author(s): Mohamad G. Ghosn; Yezeng Cheng; Kirill V. Larin
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Paper Abstract

There is increasing interest in determining drug diffusion rates in ocular tissues. In this paper we present results of our pilot investigation of depth-resolved monitoring of water diffusion in rabbit cornea using Optical Coherence Tomography (OCT) technique. We monitored changes in the local scattering coefficient of rabbit cornea in vitro as water propagated inside the tissue. Tissue hydration and saturation phases were clearly seen. The water diffusion rate was about 1.48-5cm/sec. The experimental results suggest that water diffusion rate in cornea can be potentially measured with the OCT system noninvasively with high precision and accuracy.

Paper Details

Date Published: 21 July 2006
PDF: 5 pages
Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616303 (21 July 2006); doi: 10.1117/12.696929
Show Author Affiliations
Mohamad G. Ghosn, Biomedical Engineering Program, Univ. of Houston (United States)
Yezeng Cheng, Biomedical Engineering Program, Univ. of Houston (United States)
Kirill V. Larin, Biomedical Engineering Program, Univ. of Houston (United States)


Published in SPIE Proceedings Vol. 6163:
Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Valery V. Tuchin, Editor(s)

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