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Proceedings Paper

Laser speckle techniques for studying thermally induced dynamics of blood perfusion of mice's mesentery
Author(s): Dan Zhu; Yang Weng; Ting Zhang; Qian Liu; Qingming Luo
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Paper Abstract

Measurement of blood perfusion has been playing an important role in the field of bioheat transfer and clinical thermotherapy. However, it is not easy to gain thermal induced dynamics of blood perfusion of local tissue. Laser speckle techniques we developed were valid. In this paper, we reviewed our progress on studying thermal induced dynamics of blood perfusion of mice's mesentery with laser speckle techniques which included laser speckle microscopy with CCD camera for isolate vessel and laser speckle imaging for local vessels of mesentery of mice. The principles of the two kinds of laser speckle techniques were introduced briefly. The blood perfusion of normal and tumor mice's mesentery were showed during different constant temperatures (41-45°C) by laser speckle imaging technique. Further more, the dynamics of velocity, diameter and blood perfusion for normal and tumor were compared. The results showed that tumor was more sensitive to heat than normal tissue, which accorded with pathological investigation. Finally, the quantitative relationship among the blood perfusion, the temperature-dependent and the damage-dependent was established. The model could describe successfully thermal induced dynamics of blood perfusion of mesentery for both normal and tumor mice.

Paper Details

Date Published: 21 July 2006
PDF: 11 pages
Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616302 (21 July 2006); doi: 10.1117/12.696925
Show Author Affiliations
Dan Zhu, Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Yang Weng, Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Ting Zhang, Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Qian Liu, Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6163:
Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Valery V. Tuchin, Editor(s)

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