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Proceedings Paper

Computer design of tetrapeptide CCK-4 analogues
Author(s): Pavel E. Kuznetsov; Nina B. Kuznetsova; Sergey V. Schulgin; Svetlana M. Rogacheva; Valeriy V. Sinyakov; Viktor A. Kovtun
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Paper Abstract

In this paper we propose a theoretical method of estimation of biological activity of tetrapeptide cholecystokinin (CCK- 4) analogues according to their structure. The method is based on the prospective mechanism of CCK-4 interaction with CCK-2 receptor. Electron and structural properties of CCK-4 are taken into account. The relationship structure-activity for CCK-4 analogues with the known pharmacological profile have been studied using the model of the ligand-receptor interaction.

Paper Details

Date Published: 8 August 2006
PDF: 11 pages
Proc. SPIE 6165, Saratov Fall Meeting 2005: Laser Physics and Photonics, Spectroscopy and Molecular Modeling VI, 61650T (8 August 2006); doi: 10.1117/12.696921
Show Author Affiliations
Pavel E. Kuznetsov, Saratov State Univ. (Russia)
Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Nina B. Kuznetsova, Saratov State Univ. (Russia)
Sergey V. Schulgin, Saratov State Univ. (Russia)
Svetlana M. Rogacheva, Saratov Military Institute of Radioactive, Chemical and Biological Defense (Russia)
Valeriy V. Sinyakov, Saratov State Univ. (Russia)
Viktor A. Kovtun, Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 6165:
Saratov Fall Meeting 2005: Laser Physics and Photonics, Spectroscopy and Molecular Modeling VI
Vladimir L. Derbov; Leonid A. Melnikov; Lev M. Babkov, Editor(s)

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