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Proceedings Paper

Single-cell impedance spectroscopy: maximum length sequence analysis
Author(s): Tao Sun; Nicolas G. Green; Shady Gawad; Hywel Morgan
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Paper Abstract

A novel broadband high-speed impedance spectrometer has been developed for the analysis of single biological particles in a high-throughput microfluidic cytometer. The technique is based on obtaining the impulse response of the system using maximum length sequences (MLS) as the excitation signal. The impulse response is converted into the frequency domain using Fast Fourier Transform (FFT). Theoretical modeling and simulation of a single cell suspended in the cytometer show that the MLS technique is capable of high precision single particle analysis.

Paper Details

Date Published: 14 December 2006
PDF: 10 pages
Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 64160Y (14 December 2006); doi: 10.1117/12.696633
Show Author Affiliations
Tao Sun, Univ. of Southampton (United Kingdom)
Nicolas G. Green, Univ. of Southampton (United Kingdom)
Shady Gawad, Univ. of Southampton (United Kingdom)
Hywel Morgan, Univ. of Southampton (United Kingdom)

Published in SPIE Proceedings Vol. 6416:
Biomedical Applications of Micro- and Nanoengineering III
Dan V. Nicolau, Editor(s)

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