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Proceedings Paper

Active control for droplet-based microfluidics
Author(s): Teck Hui Ting; Yit Fatt Yap; Nam-Trung Nguyen; Teck Neng Wong; John Chee Kiong Chai; Levent Yobas
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Paper Abstract

Active control of microdroplets in microchannels is an important task in droplet-based microfluidics. The break- up process of droplets at an T-junction is usually controlled passively by the fluidic resistance of the branches. We used thermal control to actively manipulate aqueous droplets in microchannels. The temperature affects both viscosity and interfacial tension between the phases. The concept was first simulated with a two-dimensional model. The simulation results show that increasing temperature at a branch can change the size ratio of the two daughter droplets from 0 to 1. That means, droplet switching is possible with this concept. Control of droplet size during the formation process and splitting process was demonstrated experimentally by varying the temperature of the branches. At a critical temperature, droplet switching can be achieved. The used control temperature of less than 40°C shows that this active control concept is suitable for biochemical applications. Thermal control promises to be a simple and effective manipulation method for droplet-based lab on a chip.

Paper Details

Date Published: 14 December 2006
PDF: 6 pages
Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 64160E (14 December 2006); doi: 10.1117/12.696496
Show Author Affiliations
Teck Hui Ting, Nanyang Technological Univ. (Singapore)
Yit Fatt Yap, Nanyang Technological Univ. (Singapore)
Nam-Trung Nguyen, Nanyang Technological Univ. (Singapore)
Teck Neng Wong, Nanyang Technological Univ. (Singapore)
John Chee Kiong Chai, Nanyang Technological Univ. (Singapore)
Levent Yobas, Institute of Microelectronics (Singapore)

Published in SPIE Proceedings Vol. 6416:
Biomedical Applications of Micro- and Nanoengineering III
Dan V. Nicolau, Editor(s)

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