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Proceedings Paper

Molecular and structural preservation of dehydrated bio-tissue for THz spectroscopy
Author(s): Gretel M. Png; Jin Wook Choi; Ian Guest; Brian W.-H. Ng; Samuel P. Mickan; Derek Abbott; Xi-Cheng Zhang
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Paper Abstract

Terahertz transmission through freshly excised biological tissue is limited by the tissue's high water content. Tissue fixation methods that remove water, such as fixation in Formalin, destroy the structural information of proteins hence are not suitable for THz applications. Dehydration is one possible method for revealing the tissue's underlying molecular structure and components. In this study, we measured the THz responses over time of dehydrating fresh, necrotic and lyophilized rat tissue. Our results show that as expected, THz absorption increases dramatically with drying and tissue freshness can be maintained through lyophilization. Dehydrated biological tissue with retained molecular structure can be useful for future laser-based THz wave molecular analysis.

Paper Details

Date Published: 14 December 2006
PDF: 9 pages
Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 64160W (14 December 2006); doi: 10.1117/12.695767
Show Author Affiliations
Gretel M. Png, Ctr. for Biomedical Engineering, The Univ. of Adelaide (Australia)
Jin Wook Choi, Ctr. for Terahertz Research, Rensselaer Polytechnic Institute (United States)
Ian Guest, NYS Dept. of Health (United States)
Brian W.-H. Ng, Ctr. for Biomedical Engineering, The Univ. of Adelaide (Australia)
Samuel P. Mickan, Ctr. for Biomedical Engineering, The Univ. of Adelaide (Australia)
Derek Abbott, Ctr. for Biomedical Engineering, The Univ. of Adelaide (Australia)
Xi-Cheng Zhang, Ctr. for Terahertz Research, Rensselaer Polytechnic Institute (United States)


Published in SPIE Proceedings Vol. 6416:
Biomedical Applications of Micro- and Nanoengineering III
Dan V. Nicolau, Editor(s)

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