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Proceedings Paper

Microfluidic device with asymmetric electrodes for cell and reagent delivery
Author(s): Daniel Lee; Guolin Xu; Hong Kiat Tay; Chun Yang; Jackie Y. Ying
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Paper Abstract

We present the design and fabrication of a micro-electromechanical system (MEMS) device for cell and particle delivery using a combination of AC electrokinetic fluidic flow and negative dielectrophoresis (DEP) force. An array of interdigitated asymmetric microelectrode pairs were used in the planar device. The electrodes produced a net charge in the surrounding fluid, generating an AC electrokinetic fluidic motion. A non-uniform electric field with low actuation frequency from the microelectrode pairs resulted in a negative DEP force, which was responsible for pushing delivery particles away from sedimentation. The experimental results showed that the flow velocity increased rapidly from 267 μm/min to 394 μm/min when the applied frequency was increased from 10 kHz to 70 kHz for a cell-suspending medium buffer solution with a conductivity of 4.7 μS/cm. A maximum delivery velocity of 801 μm/min was obtained when the buffer conductivity was increased to 47 μS/cm with an actuation frequency of 100 kHz.

Paper Details

Date Published: 20 December 2006
PDF: 6 pages
Proc. SPIE 6415, Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III, 64150U (20 December 2006); doi: 10.1117/12.695598
Show Author Affiliations
Daniel Lee, Institute of Bioengineering and Nanotechnology (Singapore)
Guolin Xu, Institute of Bioengineering and Nanotechnology (Singapore)
Hong Kiat Tay, Institute of Bioengineering and Nanotechnology (Singapore)
Nanyang Technological Univ. (Singapore)
Chun Yang, Nanyang Technological Univ. (Singapore)
Jackie Y. Ying, Institute of Bioengineering and Nanotechnology (Singapore)


Published in SPIE Proceedings Vol. 6415:
Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III
Jung-Chih Chiao; Andrew S. Dzurak; Chennupati Jagadish; David Victor Thiel, Editor(s)

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