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Proceedings Paper

The adjuvanticity of gold nanoparticles
Author(s): Lev A. Dykman; Vladimir A. Bogatyrev; Sergey A. Staroverov; Dmitry V. Pristensky; Sergey Yu. Shchyogolev; Nikolai G. Khlebtsov
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Paper Abstract

A new variant of a technique for in vivo production of antibodies to various antigens with colloidal-gold nanoparticles as carrier is discussed. With this technique we obtained highly specific and relatively high-titre antibodies to different antigens. The antibodies were tested by an immunodot assay with gold nanoparticle markers. Our results provide the first demonstration that immunization of animals with colloidal gold complexed with either haptens or complete antigens gives rise to highly specific antibodies even without the use of complete Freund's adjuvant. These findings may attest to the adjuvanticity of gold nanoparticles itself. We provide also experimental results and discussion aimed at elucidation of possible mechanisms of the discovered colloidal-gold-adjuvanticity effect.

Paper Details

Date Published: 7 July 2006
PDF: 7 pages
Proc. SPIE 6164, Saratov Fall Meeting 2005: Coherent Optics of Ordered and Random Media VI, 616404 (7 July 2006); doi: 10.1117/12.695006
Show Author Affiliations
Lev A. Dykman, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Vladimir A. Bogatyrev, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Saratov State Univ. (Russia)
Sergey A. Staroverov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Dmitry V. Pristensky, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Sergey Yu. Shchyogolev, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Saratov State Univ. (Russia)
Nikolai G. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russia)
Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 6164:
Saratov Fall Meeting 2005: Coherent Optics of Ordered and Random Media VI
Dmitry A. Zimnyakov; Nikolai G. Khlebtsov, Editor(s)

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