Share Email Print
cover

Proceedings Paper

A linear GPST-based scheme for time-domain fluorescence molecular tomography
Author(s): Feng Gao; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Fluorescence diffuse optical tomography (DOT) has attracted many attentions from the community of biomedical imaging, since it provides effective enhancement in imaging contrast. This modality is now rapidly evolving as a potential means of monitoring molecular events in small living organisms with help of molecule-specific contrast agents, referred to as fluorescence molecular tomography (FMT). FMT could greatly promote pathogenesis research, drug development, and therapeutic intervention. Although FMT in steady-state and frequency-domain modes have been promisingly demonstrated, the extension to time-domain scheme is imminent for its several unique advantages over the others. By extending the previously developed generalized pulse spectrum technique (GPST) for time-domain DOT, we propose a linear, featured-data image reconstruction algorithm for time-domain FMT that can simultaneously reconstruct both fluorescent yield and lifetime images, and validate the methodology with simulated data.

Paper Details

Date Published: 13 February 2007
PDF: 12 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64342F (13 February 2007); doi: 10.1117/12.694199
Show Author Affiliations
Feng Gao, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Yukari Tanikawa, National Institute of Advanced Industrial Science and Technology (Japan)
Yukio Yamada, Univ. of Electro-Communications (Japan)


Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

© SPIE. Terms of Use
Back to Top