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Proceedings Paper

Highly sensitive single photon detection system for multilane DNA sequencer
Author(s): Dmitri Gavrilov; Boris Gorbovitski; Georgiy Gudkov; Andrey Stepukhovich; Marina Tcherevishnik; Georgiy Tyshko; Andriy Tsupryk; Vera Gorfinkel
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Paper Abstract

A multichannel fluorescence detection system for multi-lane DNA sequencer based on single photon counting is presented. The problem of elimination of the lane cross-talk caused by both optical and electronic cross-talk between the detection lanes is discussed. A novel method for elimination of the channel cross-talk is proposed. The calibration procedure for a DNA sequencer with lane cross-talk cancellation is described. Improvement in sensitivity of a DNA sequencer setup by introducing wide collection angle optical system is discussed.

Paper Details

Date Published: 3 November 2006
PDF: 12 pages
Proc. SPIE 6372, Advanced Photon Counting Techniques, 63720B (3 November 2006); doi: 10.1117/12.685404
Show Author Affiliations
Dmitri Gavrilov, SUNY at Stony Brook (United States)
Boris Gorbovitski, SUNY at Stony Brook (United States)
Georgiy Gudkov, SUNY at Stony Brook (United States)
Andrey Stepukhovich, SUNY at Stony Brook (United States)
Marina Tcherevishnik, SUNY at Stony Brook (United States)
Georgiy Tyshko, SUNY at Stony Brook (United States)
Andriy Tsupryk, SUNY at Stony Brook (United States)
Vera Gorfinkel, SUNY at Stony Brook (United States)

Published in SPIE Proceedings Vol. 6372:
Advanced Photon Counting Techniques
Wolfgang Becker, Editor(s)

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