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Proceedings Paper

Liquid core optical ring resonator label-free biosensor array for lab-on-a-chip development
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Paper Abstract

Label-free optical biosensors offer advantages for many applications due to their simplicity and low cost compared to fluorescence detection. Thus, it is desirable to develop label-free sensors that can be integrated with advanced microfluidic systems into dense, multi-purpose biosensor arrays. One candidate technology is ring resonators, which utilize the resonating whispering gallery modes to create a strongly enhanced optical field in the sensing volume. Because of the high Q-factor of ring resonators, the optical field can be enhanced by 2-3 orders of magnitude, which leads to much smaller required light-matter interaction length and sensing volume. These are critical characteristics for dense integration into lab-on-a-chip systems. We have developed a novel label-free ring resonator sensor based on a liquid core optical ring resonator (LCORR). This system uses a glass capillary as both the fluidics and the ring resonator. With the LCORR, we have demonstrated a measurable whispering gallery mode spectral shift of 30 pm/refractive-index-unit (RIU), which leads to a detection limit of approximately 10-6 RIU. Additionally, we have achieved an estimated detection limit for protein molecules of 10 pg/mm2. These experimental demonstrations of this novel sensing system will lead to the development of highly sensitive label-free sensors that are well-suited for dense integration with advanced microfluidics for lab-on-a-chip systems.

Paper Details

Date Published: 25 October 2006
PDF: 7 pages
Proc. SPIE 6380, Smart Medical and Biomedical Sensor Technology IV, 63800F (25 October 2006); doi: 10.1117/12.684816
Show Author Affiliations
Ian M. White, Univ. of Missouri (United States)
Hongying Zhu, Univ. of Missouri (United States)
Jonathan D. Suter, Univ. of Missouri (United States)
Hesam Oveys, Univ. of Missouri (United States)
Xudong Fan, Univ. of Missouri (United States)

Published in SPIE Proceedings Vol. 6380:
Smart Medical and Biomedical Sensor Technology IV
Brian M. Cullum; J. Chance Carter, Editor(s)

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