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Proceedings Paper

Applications of imaging interferometry
Author(s): Jason Reed; Paul Wilkinson; Keith O'Doherty; Joanna Schmit; Sen Han; Josh Troke; Michael Teitell; William Klug; James Gimzewski
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Paper Abstract

Here we report application of imaging interferometry to the study of nanomechanical motion in biosensors and living biological systems. Using strobed interferometric microscopy we are able to probe the dynamic behavior of individual (100 x 500 x 1 micron) cantilevers in an eight cantilever array over frequencies from 0 - 1 MHz. In a related approach, we have developed an interferometric method to measure cell-specific mechanical signals in real time. This yields real-time diagnostic information about cell structure, metabolism and movement, along with response to chemical and physical stimuli. Our new approach makes use of "nanomirrors" fixed to the cell membrane. These mirrors act as nanoscopic displacement probes and can be interrogated, rapidly, by optical profiling metrology.

Paper Details

Date Published: 14 August 2006
PDF: 8 pages
Proc. SPIE 6293, Interferometry XIII: Applications, 629301 (14 August 2006); doi: 10.1117/12.683948
Show Author Affiliations
Jason Reed, Univ. of California, Los Angeles (United States)
Paul Wilkinson, Univ. of California, Los Angeles (United States)
Keith O'Doherty, Univ. of California, Los Angeles (United States)
Joanna Schmit, Veeco Metrology (United States)
Sen Han, Veeco Metrology (United States)
Josh Troke, Univ. of California, Los Angeles (United States)
Michael Teitell, Univ. of California, Los Angeles (United States)
William Klug, Univ. of California, Los Angeles (United States)
James Gimzewski, Univ. of California, Los Angeles (United States)


Published in SPIE Proceedings Vol. 6293:
Interferometry XIII: Applications
Erik L. Novak; Wolfgang Osten; Christophe Gorecki, Editor(s)

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