Share Email Print

Proceedings Paper

Real-time control of microreactors by Raman spectroscopy
Author(s): Chetan Shende; Paul Maksymiuk; Frank Inscore; Stuart Farquharson
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

In recent years a paradigm in chemical manufacturing has emerged, numbering-up production instead of the traditional scaling-up. This new approach employs nanoliter to milliliter reactors that increase control of reaction pathways, product choice and yield. These small-scale reactors virtually eliminate mixing and heat transfer problems associated with large-scale reactors that often limit yield. The value of small-scale reactors is being recognized by the pharmaceutical industry where only small-scale synthesis is required until clinical trials are complete, at which time fullscale production needs to be accomplished in the shortest possible time. One of the most often used reaction steps during the synthesis of pharmaceuticals is protecting carboxylic acid groups by esterification. We have been developing Raman spectroscopy as a process analytical tool to monitor and control chemistry in such small-scale reactors. Here we present Raman spectra of the esterification of benzoic acid performed in a 5-mL batch reactor.

Paper Details

Date Published: 20 October 2006
PDF: 6 pages
Proc. SPIE 6371, Photonic Sensing Technologies, 637106 (20 October 2006); doi: 10.1117/12.682536
Show Author Affiliations
Chetan Shende, Real-Time Analyzers, Inc. (United States)
Paul Maksymiuk, Real-Time Analyzers, Inc. (United States)
Frank Inscore, Real-Time Analyzers, Inc. (United States)
Stuart Farquharson, Real-Time Analyzers, Inc. (United States)

Published in SPIE Proceedings Vol. 6371:
Photonic Sensing Technologies
Michael A. Marcus; Brian Culshaw; John P. Dakin, Editor(s)

© SPIE. Terms of Use
Back to Top