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Proceedings Paper

Opto-bio-fluidic modeling of bioanalytical and biomedical microdevices
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Paper Abstract

Optical technology is rapidly finding novel applications in several exiting bioanalytical, biological, and biomedical applications. Optical beams are increasingly used for bio-fluidic sample manipulation in BioMEMS devices replacing convectional mechanical, electrostatic, and electrokinetic methods. This paper presents novel multiphysics computational approach for modeling optical interaction with fluidic, thermal, mechanical, and biological processes. We present a model of optical manipulation of particles and biological cells with laser beams. Computational results are compared to available experimental data from laboratory experiments and from practical engineered optical bio microdevices. The modeling approach is demonstrated on selected specific applications of optical manipulation of micro spheres, micro cylinders, and optical manipulation and sorting of biological cells in microfluidic cytometers.

Paper Details

Date Published: 11 September 2006
PDF: 13 pages
Proc. SPIE 6326, Optical Trapping and Optical Micromanipulation III, 63261N (11 September 2006); doi: 10.1117/12.681384
Show Author Affiliations
Andrzej J. Przekwas, CFD Research Corp. (United States)
Zbigniew Sikorski, Univ. of Tennessee Space Institute (United States)

Published in SPIE Proceedings Vol. 6326:
Optical Trapping and Optical Micromanipulation III
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

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