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Proceedings Paper

Image-based analysis of the internal microstructure of bone replacement scaffolds fabricated by 3D printing
Author(s): Stephan H. Irsen; Barbara Leukers; Björn Bruckschen; Carsten Tille; Hermann Seitz; Felix Beckmann; Bert Müller
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Paper Abstract

Rapid Prototyping and especially the 3D printing, allows generating complex porous ceramic scaffolds directly from powders. Furthermore, these technologies allow manufacturing patient-specific implants of centimeter size with an internal pore network to mimic bony structures including vascularization. Besides the biocompatibility properties of the base material, a high degree of open, interconnected porosity is crucial for the success of the synthetic bone graft. Pores with diameters between 100 and 500 μm are the prerequisite for vascularization to supply the cells with nutrients and oxygen, because simple diffusion transport is ineffective. The quantification of porosity on the macro-, micro-, and nanometer scale using well-established techniques such as Hg-porosimetry and electron microscopy is restricted. Alternatively, we have applied synchrotron-radiation-based micro computed tomography (SRμCT) to determine the porosity with high precision and to validate the macroscopic internal structure of the scaffold. We report on the difficulties in intensity-based segmentation for nanoporous materials but we also elucidate the power of SRμCT in the quantitative analysis of the pores at the different length scales.

Paper Details

Date Published: 7 September 2006
PDF: 10 pages
Proc. SPIE 6318, Developments in X-Ray Tomography V, 631809 (7 September 2006); doi: 10.1117/12.681149
Show Author Affiliations
Stephan H. Irsen, Caesar Research Ctr. (Germany)
Barbara Leukers, Caesar Research Ctr. (Germany)
Björn Bruckschen, Caesar Research Ctr. (Germany)
Carsten Tille, Caesar Research Ctr. (Germany)
Hermann Seitz, Caesar Research Ctr. (Germany)
Felix Beckmann, GKSS Research Ctr., Geesthacht (Germany)
Bert Müller, ETH Zürich (Switzerland)

Published in SPIE Proceedings Vol. 6318:
Developments in X-Ray Tomography V
Ulrich Bonse, Editor(s)

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