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Proceedings Paper

Microtomography of magnesium implants in bone and their degradation
Author(s): Frank Witte; Jens Fischer; Jens Nellesen; Felix Beckmann
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Paper Abstract

Biodegradable metal implants for musculoskeletal and intravascular applications made of magnesium alloys have been shown to degrade in-vivo by corrosion. The in vivo corrosion of magnesium alloys has the potential to provide a new mechanism which will allow metal implants to be applied in musculoskeletal surgery as biodegradable implants. This would particularly be true if magnesium alloys with predictable in vivo corrosion rates could be developed. Since the magnesium corrosion process depends on the corrosive environment, the corrosion rates of magnesium alloys under standard in-vitro environmental conditions are not directly comparable to results obtained from an animal model. Synchrotron-radiation based microtomography (SRμCT) enabled us to investigate non-destructively the in vivo corrosion as well as the osteointegration at the implant-bone interphase at a high spatial resolution. Corrosion morphology and its metallurgical quantification of pit formation could be obtained. Since the alloying elements of magnesium alloys have significant importance for the degradation process in biological environments the biocompatibility depending on their local concentration and distribution has to be investigated. For this purpose we used element-specific SRμCT to show the spatial distribution without destroying the bone-implant interphase. The SRμCT setup at HASYLAB at DESY will be an excellent tool in the future to develop suitable magnesium alloys and magnesium implants for special medical applications.

Paper Details

Date Published: 7 September 2006
PDF: 9 pages
Proc. SPIE 6318, Developments in X-Ray Tomography V, 631806 (7 September 2006); doi: 10.1117/12.679844
Show Author Affiliations
Frank Witte, Hannover Medical School (Germany)
Jens Fischer, Hannover Medical School (Germany)
Jens Nellesen, Univ. of Dortmund (Germany)
Felix Beckmann, GKSS-Research Ctr. (Germany)

Published in SPIE Proceedings Vol. 6318:
Developments in X-Ray Tomography V
Ulrich Bonse, Editor(s)

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