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Proceedings Paper

Study of molecular mechanisms of UV-induced aggregation of crystallins and possibility of maintaining eye lens transparency
Author(s): L. V. Soustov; E. V. Chelnokov; N. M. Bityurin; A. L. Kiselev; V. V. Nemov; Yu. V. Sergeev; M. A. Ostrovsky
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Paper Abstract

The effect of D-pantethine and L-carnosine on the rate of UV-induced (XeC1 laser λ = 308 nm) aggregation of a mixture of βL-crystallin and α-crystallin is studied. We also demonstrate that the suggested by us combination of short-chain peptides shows better protective properties with respect to UV-induced aggregation than known anti-cataract agents.

Paper Details

Date Published: 19 May 2006
PDF: 8 pages
Proc. SPIE 6257, ICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry, 62570X (19 May 2006); doi: 10.1117/12.678391
Show Author Affiliations
L. V. Soustov, Institute of Applied Physics (Russia)
E. V. Chelnokov, Institute of Applied Physics (Russia)
N. M. Bityurin, Institute of Applied Physics (Russia)
A. L. Kiselev, Institute of Applied Physics (Russia)
V. V. Nemov, Institute of Epidemiology and Microbiology (Russia)
Yu. V. Sergeev, National Eye Institute of National Institutes of Health (United States)
M. A. Ostrovsky, Institute of Biochemical Physics (Russia)


Published in SPIE Proceedings Vol. 6257:
ICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry
Sergey N. Bagayev; Andrey Chikishev; Alexander Dmitriev; Martial Ducloy; Tony Heinz; Vladilen Letokhov; Alexander Shkurinov; Hiroaki Takahashi, Editor(s)

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