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Proceedings Paper

Plasmon-controlled fluorescence: a new detection technology
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Paper Abstract

Fluorescence is widely used in biological research. Future advances in biology and medicine often depend on the advances in the capabilities of fluorescence measurements. In this overview paper we describe how a combination of fluorescence, and plasmonics, and nanofabrication can fundamentally change and increase the capabilities of fluorescence technology. This change will be based on the use of surface plasmons which are collective oscillations of free electrons in metallic surfaces and particles. Surface plasmon resonance is now used to measure bioaffinity reactions. However, the uses of surface plasmons in biology are not limited to their optical absorption or extinction. We have shown that fluorophores in the excited state can create plasmons which radiate into the far field; additionally fluorophores in the ground state can interact with and be excited by surface plasmons. These interactions suggest that the novel optical absorption and scattering properties of metallic nanostructures can be used to control the decay rates, location and direction of fluorophore emission. We refer to this technology as plasmon-controlled fluorescence. We predict that plasmon-controlled fluorescence (PCF) will result in a new generation of probes and devices. PCF is likely to allow design of structures which enhance emission at specific wavelengths and the creation of new devices which control and transport the energy from excited fluorophores in the form of plasmons, and then convert the plasmons back to light.

Paper Details

Date Published: 23 February 2006
PDF: 15 pages
Proc. SPIE 6099, Plasmonics in Biology and Medicine III, 609909 (23 February 2006); doi: 10.1117/12.673106
Show Author Affiliations
Joseph R. Lakowicz, Univ. of Maryland at Baltimore (United States)
Mustafa H. Chowdhury, Univ. of Maryland at Baltimore (United States)
Krishanu Ray, Univ. of Maryland at Baltimore (United States)
Jian Zhang, Univ. of Maryland at Baltimore (United States)
Yi Fu, Univ. of Maryland at Baltimore (United States)
Ramachandram Badugu, Univ. of Maryland at Baltimore (United States)
Chandran R. Sabanayagam, Univ. of Maryland at Baltimore (United States)
Kazimierz Nowaczyk, Univ. of Maryland at Baltimore (United States)
Henryk Szmacinski, Univ. of Maryland at Baltimore (United States)
Kadir Aslan, Univ. of Maryland Biotechnology Institute (United States)
Chris D. Geddes, Univ. of Maryland at Baltimore (United States)
Univ. of Maryland Biotechnology Institute (United States)


Published in SPIE Proceedings Vol. 6099:
Plasmonics in Biology and Medicine III
Tuan Vo-Dinh; Joseph R. Lakowicz; Zygmunt Gryczynski, Editor(s)

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