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Proceedings Paper

Submicro foaming in biopolymers by UV pulsed laser irradiation
Author(s): Mohamed Oujja; Esther Rebollar; Solenne Gaspard; Concepción Abrusci; Fernando Catalina; Sylvain Lazare; Marta Castillejo
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Paper Abstract

Microstructuring of polymers and biopolymers is of application in medical technology and biotechnology. Using different fabrication techniques three-dimensionally shaped and micro structured constructs can be developed for drug release and tissue engineering. As an alternative method, laser microstructuring offers a series of advantages including high resolution capability, low heat deposition in the substrate and high level of flexibility. In this work we present evidence of laser microfoam formation in collagen and gelatine by nanosecond pulsed laser irradiation in the UV at 248 and 266 nm. Irradiation at 355 nm produces melting followed by resolidification of the substrate, whereas irradiation at 532 and 1064 nm induces the formation of craters of irregular contours. Single pulse irradiation of a collagen film with an homogenized KrF microbeam yields a 20 μm thick expanded layer, which displays the interesting features of a nanofibrous 3-dimensional network with open cells. In gelatine, irradiation at 248 and 266 nm produces similar morphological modifications. The effect of the structural properties of the substrate on the laser induced microfoam is studied by comparing gelatines differing in gel strength (Bloom values 225 and 75) and in crosslinking degree. While results are discussed on the basis of thermal and photomechanical mechanisms and of the role played by the water content of the substrates, it is thought that such structures could have a biomimic function in future 3D cell culture devices for research.

Paper Details

Date Published: 7 June 2006
PDF: 9 pages
Proc. SPIE 6261, High-Power Laser Ablation VI, 62611L (7 June 2006); doi: 10.1117/12.668958
Show Author Affiliations
Mohamed Oujja, Institute of Physical Chemistry Rocasolano, CSIC (Spain)
Esther Rebollar, Institute of Physical Chemistry Rocasolano, CSIC (Spain)
Solenne Gaspard, Institute of Physical Chemistry Rocasolano, CSIC (Spain)
Concepción Abrusci, Institute of Polymer Science and Technology, CSIC (Spain)
Fernando Catalina, Institute of Polymer Science and Technology, CSIC (Spain)
Sylvain Lazare, LPCM, CNRS, Univ. de Bordeaux I (France)
Marta Castillejo, Institute of Physical Chemistry Rocasolano, CSIC (Spain)


Published in SPIE Proceedings Vol. 6261:
High-Power Laser Ablation VI
Claude R. Phipps, Editor(s)

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