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Proceedings Paper

In vivo manipulation of biological systems with femtosecond laser pulses
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Paper Abstract

Femtosecond laser pulses have the unique ability to deposit energy into a microscopic volume in the bulk of a material that is transparent to the laser wavelength without affecting the surface of the material. Here we review the use of this capability to disrupt specifically targeted structures in live cells and animals with the goal of elucidating function and modeling disease states. Particular attention will be paid to recent work that uses femtosecond laser disruption to injure cerebral blood vessels that lie below the brain surface in a live, anesthetized rat. By varying the degree of injury, the vessel can be made to leak blood plasma, to rupture, or to clot. This technique thus provides a versatile model of cerebrovascular disorders such as small-scale stroke.

Paper Details

Date Published: 7 June 2006
PDF: 10 pages
Proc. SPIE 6261, High-Power Laser Ablation VI, 62611J (7 June 2006); doi: 10.1117/12.668886
Show Author Affiliations
Nozomi Nishimura, Univ. of California, San Diego (United States)
Cornell Univ. (United States)
Chris B. Schaffer, Cornell Univ. (United States)
David Kleinfeld, Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 6261:
High-Power Laser Ablation VI
Claude R. Phipps, Editor(s)

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