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Proceedings Paper

Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system
Author(s): Nzola De Magalhães; Lih-Huei L. Liaw; Linda Li; Angela Liogys; Steen J. Madsen; Henry Hirschberg; Bruce J. Tromberg
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Paper Abstract

An in-vivo tumor model composed of multicellular human glioma spheroids implanted on a shell-less chorioallantoic membrane (CAM), has been developed. Following removal of a portion of the ectodermal epithelium layer of the CAM, human glioma spheroids were implanted on day 7 of embryonic development. Tumor invasion, rapid growth and vasculature formation were observed 7 days post implantation. Single tumor cell migration towards blood vessels, angiogenesis and satellite tumor growth were also evident. The human tumor/CAM model is being used to examine the effects of combined ALA PDT and anti-angiogenic agents. The shell-less CAM is well suited for topical, i.p. and i.v. photosensitizer and/or drug application.

Paper Details

Date Published: 22 February 2006
PDF: 6 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607830 (22 February 2006); doi: 10.1117/12.668795
Show Author Affiliations
Nzola De Magalhães, Beckman Laser Institute (United States)
Lih-Huei L. Liaw, Beckman Laser Institute (United States)
Linda Li, Beckman Laser Institute (United States)
Angela Liogys, Beckman Laser Institute (United States)
Steen J. Madsen, Univ. of Nevada/Las Vegas (United States)
Rikshospitalet (Norway)
Henry Hirschberg, Beckman Laser Institute (United States)
Rikshospitalet (Norway)
Bruce J. Tromberg, Beckman Laser Institute (United States)

Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory; Nikiforos Kollias; Reza S. Malek; Michael D. Lucroy; Henry Hirschberg; Brian Jet-Fei Wong; Eugene A. Trowers; Werner T.W. de Riese; Justus F. R. Ilgner; Steen J. Madsen; Lloyd P. Tate; Haishan Zeng; Guillermo J. Tearney; Bernard Choi, Editor(s)

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