Share Email Print
cover

Proceedings Paper

Ru, Os, Rh mixed-metal complexes are a potential novel class of oxygen independent photosensitizers for PDT
Author(s): Brian Storrie; Alvin Holder; Karen Jenks Brewer
Format Member Price Non-Member Price
PDF $17.00 $21.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Mixed-metal supramolecular complexes coupling Ru and Os light absorber units to a central, reactive Rh site have been designed of the type [{(bpy)2M(dpp)}2RhCl2]5+. These complexes possess intense metal-to-ligand charge transfer transitions when excited at 500-700 nm making them good light absorbers. The presence of the Rh site introduces low lying metal-to-metal charge transfer states that are capable of visible light induced photocleavage of DNA via an oxygen independent pathway.1 We report here a study of the photodynamic action of supramolecular mixed-metal complexes showing that these systems inhibit cell replication after exposure to light while displaying no impact on cell replication in the dark. This photodynamic action has been studied using cultured Vero cells with a pre-incubation with the complexes, rinsing to remove complex from the media, followed by photo-activation and cell growth assay. The photodynamic action of this new series of complexes can be tuned as a function of components of the supramolecular assembly and complexes capable of coupling to targeting proteins and fluorescent reporter groups have been synthesized.

Paper Details

Date Published: 6 March 2006
PDF: 7 pages
Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 61391G (6 March 2006); doi: 10.1117/12.668630
Show Author Affiliations
Brian Storrie, Univ. of Arkansas for Medical Sciences (United States)
Alvin Holder, Virginia Polytechnic Institute and State Univ. (United States)
Karen Jenks Brewer, Virginia Polytechnic Institute and State Univ. (United States)


Published in SPIE Proceedings Vol. 6139:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
David Kessel, Editor(s)

© SPIE. Terms of Use
Back to Top