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Proceedings Paper

Synthesis and properties of quantum dots optical probes for bio-imaging
Author(s): Tian-Cai Liu; Zhen-Li Huang; Hai-Qiao Wang; Yuan-Di Zhao; Qing-Ming Luo
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Paper Abstract

A novel green synthesis of semiconductor nanoparticles was introduced and it was used as optical probes for bio-imaging. Quantum dots are known as <10nm scaled semiconductor nanoparticles, which could dramatically improve fluorescent imaging. Since these nanocrystals act as robust broadly tunable nano-emitters that can be excited by a single light source, they could pride significant advantages over current labels (e.g. traditional organic dyes, isotope and fluorescent proteins) in vitro and in vivo. As for a novel green synthesis, the usage of dangerous organic composites under rigorously air-free conditions was avoided, and ZnS-capped CdSe semiconductor nanoparticles was prepared economically. And the surface of as- synthesized nanoparticle would be modified by hydrophilic molecules for optical bio-probes. Moreover, such optical probes under aqueous biological conditions could maintain many characters: economy, photostability, colloidal stability, efficient fluorescence, low non-specific adsorption, biological compatibility and validity for multiplex assays.

Paper Details

Date Published: 2 February 2006
PDF: 7 pages
Proc. SPIE 6026, ICO20: Biomedical Optics, 60261I (2 February 2006); doi: 10.1117/12.667678
Show Author Affiliations
Tian-Cai Liu, Huazhong Univ. of Science and Technology (China)
Zhen-Li Huang, Huazhong Univ. of Science and Technology (China)
Hai-Qiao Wang, Huazhong Univ. of Science and Technology (China)
Yuan-Di Zhao, Huazhong Univ. of Science and Technology (China)
Qing-Ming Luo, Huazhong Univ. of Science and Technology (China)

Published in SPIE Proceedings Vol. 6026:
ICO20: Biomedical Optics
Gert von Bally; Qingming Luo, Editor(s)

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