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Proceedings Paper

Analysis of human breast tissues with Raman microspectroscopy
Author(s): Gang Liu; Lin Zhang; Jianhong Liu; Fan Yu; Shizhong Sun
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Paper Abstract

Raman microspectroscopy was used to study normal, benign and malignant human breast tissues. The Raman spectrum of normal breast tissue recorded with 514.5 nm line of Ar+ laser excitation contains features attributed to carotenoids and lipids. The CH2 bending mode near 1447 cm-1 in normal tissue shifts up to 1454 cm-1 in diseased tissues (benign and malignant). The band near 1660 cm-1 in normal tissue is narrow and sharp; whereas the band is broaden in the diseased tissues. In the region of C-H stretching mode, the 2902-/2860-cm-1 intensity ratio shows differences among normal, benign and malignant breast tissues. The ratio is the smallest in carcinoma tissue. The observed spectra differences may be used to probe breast lesion. The results show that Raman spectroscopic technique may have clinical applications.

Paper Details

Date Published: 2 February 2006
PDF: 6 pages
Proc. SPIE 6026, ICO20: Biomedical Optics, 60260J (2 February 2006); doi: 10.1117/12.667137
Show Author Affiliations
Gang Liu, Yunnan Normal Univ. (China)
Lin Zhang, First Hospital/Kunming Medical College (China)
Jianhong Liu, Yunnan Normal Univ. (China)
Fan Yu, Yunnan Univ. (China)
Shizhong Sun, Yunnan Normal Univ. (China)


Published in SPIE Proceedings Vol. 6026:
ICO20: Biomedical Optics
Gert von Bally; Qingming Luo, Editor(s)

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