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Proceedings Paper

Photothermal effect in the tissue during photodynamic therapy
Author(s): Zhongming Li; Zhenxi Zhang
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Paper Abstract

Based on the Pennes' bio-heat transfer equation, temperature distribution in the tissue during PDT is analyzed in theory. The study indicates that laser heat source could be formed in tissue during laser irradiation, which results in the temperature rising in one-dimensional space. The rising of tissue temperature increases in exponent with time and decreases in exponent with the distance from laser irradiation position.. There exists a minimal light dosage threshold during the photothermal interaction between laser and bio-tissue. When the light dosage is lower than the critical threshold, the laser irradiation will not produce thermal effect. The threshold dosage, which depends on the optical and thermal properties of bio-tissue, increases in exponent with the distance from laser irradiating point along the direction of incident light.

Paper Details

Date Published: 2 February 2006
PDF: 4 pages
Proc. SPIE 6026, ICO20: Biomedical Optics, 60260G (2 February 2006); doi: 10.1117/12.667131
Show Author Affiliations
Zhongming Li, Xi’an Jiaotong Univ. (China)
Xianning Univ. (China)
Zhenxi Zhang, Xi’an Jiaotong Univ. (China)

Published in SPIE Proceedings Vol. 6026:
ICO20: Biomedical Optics
Gert von Bally; Qingming Luo, Editor(s)

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