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Proceedings Paper

Application of HATR-FTIR spectroscopy to the analysis of nifedipine tablets
Author(s): Cungui Cheng; Danting Li; Xinghai Liu; Jianjun Sheng; Menhai Fan; Xiaodan Li
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Paper Abstract

In recent years, FTIR has been found its wider application in analysis processes of pharmaceutical solids. This is, in part, thanks to the development of powerful multivariate quantitative techniques, such as partial least-squares (PLS) modeling software and the emergence of some new reflectance sampling techniques which allow direct measurement of the IR spectrum of solids in their native states. Horizontal Attenuated Total Reflectance (HATR) is a quite popular sampling technique in recent years. In this work, the feasibility of the Horizontal Attenuated Total Reflectance Infrared Spectroscopy (HATR-FTIR) to the quantitative and quantitative analysis of nimodipine tablets is investigated. Quantitative analysis of nimodipine is carried out by using a classical least-squares for areas procedure. Obtained from validated samples of nimodipine, quantitative results demonstrate clearly the strong potential of HATR-FTIR technique through using quantitative analysis of nimodipine content of pharmaceutical tablets.

Paper Details

Date Published: 9 December 2005
PDF: 6 pages
Proc. SPIE 6024, ICO20: Optical Devices and Instruments, 60240K (9 December 2005); doi: 10.1117/12.666826
Show Author Affiliations
Cungui Cheng, Zhejiang Normal Univ. (China)
Danting Li, Zhejiang Normal Univ. (China)
Xinghai Liu, NanKai Univ. (China)
Jianjun Sheng, Xiamen Univ. (China)
Menhai Fan, Zhejiang Normal Univ. (China)
Xiaodan Li, Zhejiang Normal Univ. (China)

Published in SPIE Proceedings Vol. 6024:
ICO20: Optical Devices and Instruments
James C. Wyant; X. J. Zhang, Editor(s)

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