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Proceedings Paper

Principal component analysis of bacteria using surface-enhanced Raman spectroscopy
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Paper Abstract

Surface-enhanced Raman scattering (SERS) provides rapid fingerprinting of biomaterial in a non-destructive manner. The problem of tissue fluorescence, which can overwhelm a normal Raman signal from biological samples, is largely overcome by treatment of biomaterials with colloidal silver. This work presents a study into the applicability of qualitative SER spectroscopy with principal component analysis (PCA) for the discrimination of four biological threat simulants; Bacillus globigii, Pantoea agglomerans, Brucella noetomae, and Yersinia rohdei. We also demonstrate differentiation of gram-negative and gram-positive species and as well as spores and vegetative cells of Bacillus globigii.

Paper Details

Date Published: 19 May 2006
PDF: 8 pages
Proc. SPIE 6218, Chemical and Biological Sensing VII, 62180G (19 May 2006); doi: 10.1117/12.664502
Show Author Affiliations
Jason Guicheteau, U.S. Army Edgewood Chemical Biological Ctr. (United States)
Steven D. Christesen, U.S. Army Edgewood Chemical Biological Ctr. (United States)


Published in SPIE Proceedings Vol. 6218:
Chemical and Biological Sensing VII
Patrick J. Gardner; Augustus W. Fountain, Editor(s)

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