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Proceedings Paper

Short-pulse laser propagation through tissue medium for tumor detection
Author(s): Gopalendu Pal; Kunal Mitra; Tuan Vo-Dinh
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Paper Abstract

The objective of this paper is to perform a comprehensive experimental and numerical analysis of the short pulse laser interaction with tissue medium with the goal of tumor / cancer diagnostics. For short pulse laser source, the shape of output signal is a function of the optical properties of the medium and hence the scattered temporal optical signal helps in understanding of the medium characteristics. Initially experiments are performed on tissue phantoms imbedded with inhomogeneities in order to optimize the time-resolved optical detection scheme. Both the temporal and the spatial profiles of the scattered reflected and transmitted optical signals are compared with the numerical modeling results obtained by solving the transient radiative transport equation using the discrete ordinates technique. Next experiments are performed on in vitro rat tissue samples to characterize the interaction of light with skin layers and to validate the time varying optical signatures with the numerical model. The numerical modeling results and the experimental measurements are in excellent agreement for the different parameters studied in this paper. The final step is to perform in vivo imaging of anaesthetized rats with tumor-promoting agents injected inside skin tissues in order to demonstrate the feasibility of the technique in detecting tumors in animal model.

Paper Details

Date Published: 25 February 2006
PDF: 12 pages
Proc. SPIE 6080, Advanced Biomedical and Clinical Diagnostic Systems IV, 608005 (25 February 2006); doi: 10.1117/12.664121
Show Author Affiliations
Gopalendu Pal, Florida Institute of Technology (United States)
Kunal Mitra, Florida Institute of Technology (United States)
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)


Published in SPIE Proceedings Vol. 6080:
Advanced Biomedical and Clinical Diagnostic Systems IV
Gerald E. Cohn; Warren S. Grundfest; David A. Benaron; Tuan Vo-Dinh, Editor(s)

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