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Proceedings Paper

Fluorescent core-shell silica nanoparticles: an alternative radiative materials platform
Author(s): Erik Herz; Andrew Burns; Stephanie Lee; Prabuddha Sengupta; Daniel Bonner; Hooisweng Ow; Chekesha Liddell; Barbara Baird; Ulrich Wiesner
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Paper Abstract

We report on monodisperse fluorescent core-shell silica nanoparticles (C dots) with enhanced brightness and photostability as compared to parent free dye in aqueous solution. Dots containing either tetramethylrhodamine or 7-nitrobenz-2-oxa-1,3-diazole dyes with diameters ranging from tens of nanometers to microns are discussed. The benefits of the core-shell architecture are described in terms of enhanced fluorescent yield of the fluorophores in the quasi-solid-state environment within the particle as compared with parent free dye in water. Several applications of these particles in the fields of photonics and the life sciences are discussed. Specifically, fluorescent core-shell silica nanoparticles are investigated as an active medium for photonic building blocks assembled on zinc sulfide-based seed particles. Initial assembly results for these composite raspberry structures are shown. Finally, applications in the life sciences are explored, including targeting of specific antibody receptors using these single-emission nanoparticles. We expand on single-emission core-shell architecture to incorporate environmentally-sensitive fluorophores to create quantitative ratiometric nanoscale sensors capable of interrogating chemical concentrations on the sub-cellular to molecular levels and demonstrate initial results of intracellular pH imaging. The concept of a single particle laboratory (SPL) is introduced as an active investigator of its environment.

Paper Details

Date Published: 4 April 2006
PDF: 12 pages
Proc. SPIE 6096, Colloidal Quantum Dots for Biomedical Applications, 609605 (4 April 2006); doi: 10.1117/12.661782
Show Author Affiliations
Erik Herz, Cornell Univ. (United States)
Andrew Burns, Cornell Univ. (United States)
Stephanie Lee, Cornell Univ. (United States)
Prabuddha Sengupta, Cornell Univ. (United States)
Daniel Bonner, Cornell Univ. (United States)
Hooisweng Ow, Hybrid Silica Technologies (United States)
Chekesha Liddell, Cornell Univ. (United States)
Barbara Baird, Cornell Univ. (United States)
Ulrich Wiesner, Cornell Univ. (United States)

Published in SPIE Proceedings Vol. 6096:
Colloidal Quantum Dots for Biomedical Applications
Marek Osinski; Kenji Yamamoto; Thomas M. Jovin, Editor(s)

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