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Proceedings Paper

Colloidal quantum dots produce current bursts in lipid bilayers
Author(s): Sujatha Ramachandran; Robert H. Blick; Daniel W. van der Weide
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Paper Abstract

Inorganic semiconductor nanocrystals, also known as quantum dots (QDs), are interesting as as fluorescent labels in biological studies. We have found that introduction of CdSe QDs to the vicinity of black lipid membranes (BLMs) results in current bursts through the membranes with bias voltage. These current bursts resemble those of the peptaibol class of antibiotics such as alamethicin and trichorzins, and are dependent both on voltage level and on concentration of the QDs applied to the membrane. Our data suggest that QDs with dipole moments similar to alamethicin are influenced by an external electric field, which creates a torque promoting insertion into the BLM, and a simple model predicts that at least three QDs can aggregate to form a pore leading to a macroscopic conductance.

Paper Details

Date Published: 27 March 2006
PDF: 4 pages
Proc. SPIE 6096, Colloidal Quantum Dots for Biomedical Applications, 60961F (27 March 2006); doi: 10.1117/12.661773
Show Author Affiliations
Sujatha Ramachandran, Univ. of Wisconsin, Madison (United States)
Robert H. Blick, Univ. of Wisconsin, Madison (United States)
Daniel W. van der Weide, Univ. of Wisconsin, Madison (United States)

Published in SPIE Proceedings Vol. 6096:
Colloidal Quantum Dots for Biomedical Applications
Marek Osinski; Kenji Yamamoto; Thomas M. Jovin, Editor(s)

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