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Proceedings Paper

Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)
Author(s): Mariela Aguilar; Hideo Yamamoto; Edgar Espana; Ana Carolina Acosta; Marcia Orozco; Mohamed Aly; Esdras Arrieta; Eleut Hernandez; John Martin; Sander Dubovy; William Smiddy; Leonard Pinchuk; Jean-Marie Parel
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Paper Abstract

Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1,2 Introduction: Scleral encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The FDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently FDA approved for use in a cardiovascular drug eluting stent (TAXUSTM, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.

Paper Details

Date Published: 7 March 2006
PDF: 8 pages
Proc. SPIE 6138, Ophthalmic Technologies XVI, 61381S (7 March 2006); doi: 10.1117/12.661174
Show Author Affiliations
Mariela Aguilar, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Univ. of Miami (United States)
Hideo Yamamoto, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Edgar Espana, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Ana Carolina Acosta, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Marcia Orozco, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Univ. of Miami (United States)
Mohamed Aly, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Esdras Arrieta, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Eleut Hernandez, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
John Martin, InnFocus LLC (United States)
Sander Dubovy, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
William Smiddy, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Leonard Pinchuk, Univ. of Miami (United States)
InnFocus LLC (United States)
Jean-Marie Parel, Bascom Palmer Eye Institute, Univ. of Miami Miller School of Medicine (United States)
Univ. of Miami (United States)
Univ. of Liège (Belgium)


Published in SPIE Proceedings Vol. 6138:
Ophthalmic Technologies XVI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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